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KMID : 0616120160470020165
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Korean Journal of Pharmacognosy
2016 Volume.47 No. 2 p.165 ~ p.171
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Anti-inflammatory Effects of MeOH Extract of Corylopsis gotoana Uyeki
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Lee Ha-Na
Cha Dong-Seok
Jeon Hoon
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Abstract
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Corylopsis gotoana (Hamamelidaceae) has been used as a traditional medicine for the treatment various diseases including cold, edema and vomiting. However, previous studies regarding component analysis and pharmacological actions of C. gotoana are extremely limited until now. In this study, we investigated anti-inflammatory activities of the methanolic extract of the twigs of Corylopsis gotoana (MCG) both in vitro and in vivo. MCG effectively inhibited excessive NO production in IFN-g and LPS-stimulated mouse peritoneal macrophages without notable cytotoxicity. In addition, we also found that MCG could attenuate the expression of inflammatory mediators such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). We further tested in vivo anti-inflammatory activity of MCG using paw edema mouse model. Herein, MCG demonstrated significant suppression on the paw edema induced by both of trypsin and carrageenan. These results indicated that MCG has potent anti-inflammatory potential and may be useful for prevention and treatments of inflammatory diseases.
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KEYWORD
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Corylopsis gotoana Uyeki, Anti-inflammation, Nitric oxide, Paw edema
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